RAF Typhoon FGR4s have conducted a mission with French warplanes in a combined operation against an hidden munitions depot in Syria operated by the IS group, according to the UK's MoD.
The site, pinpointed through intelligence, was assessed as storing arms and explosives, the announcement noted, and was located in mountainous terrain just to the north of Palmyra in central Syria.
"Our aircraft employed precision-guided Paveway IV munitions to hit a series of approach shafts down to the site... early reports indicate the target was engaged successfully," the ministry announced.
There was no evidence of any civilian casualties in the attack late on Saturday and all the aircraft returned safely, the MoD added.
The British jets were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as ISIS - imposed extremist governance over parts of Syria and Iraq until 2019.
"This operation shows our UK leadership, and commitment to stand shoulder to shoulder with our partners, to eliminate any re-emergence of Daesh and their dangerous and violent ideologies in the region," Britain's Defence Chief John Healey stated.
RAF aircraft have carried out patrols over Syrian airspace to "prevent any efforts to regroup" of Islamic State after its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I must thank all the members of our armed forces who took part in this mission for their skill and their bravery," he commented. "They were part of numerous British troops deployed over the festive period. This operation, to take out dangerous terrorists who pose a risk to our way of life, demonstrates how our armed forces are always on standby, throughout the year, protecting the UK within its borders and strong abroad."
In December, the American forces executed what it called a "large-scale strike" against IS targets in the country, following an ambush resulted in the deaths of two US troops and a local interpreter in Palmyra.
The U.N. estimates IS still boasts roughly 5-7 thousand militants in Iraq and Syria.